Научная электронная библиотека

Монографии, изданные в издательстве Российской Академии Естествознания

ПАРАТГОРМОН-РОДСТВЕННЫЙ ПРОТЕИН. 2-е издание переработанное и дополненное

Курзанов А. Н., Ледванов М. Ю., Быков И. М., Медведев В. Л., Стрыгина Е. А., Бизенкова М. Н., Заболотских Н. В., Ковалев Д. В., Стукова Н. Ю.,

Список литературы к главе 3

1. Aarts M.M., Davidson D., Corluka A. et al. Parathyroid hormone-related protein promotes quiescence and survival of serum-deprived chondrocytes by inhibiting rRNA synthesis. J Biol Chem. 2001; 276 (41): 37934-37943.

2. Abbas S.K., Pickar D.W., Rodda C.P. et al. Stimulation of ovine placental calcium transport by purified natural and recombinant parathyroid hormone-related protein (PTHrP) preparations. QJ Exp Physiol 1989; 74: 549-552.

3. Abou-Samra A.B., Juppner H., Force T., Freeman M.W., Kong X.F., Schipani E., Urena P., Richards J., Bonventre J.V., Potts J.T., Jr. et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both camp and inositol trisphosphates and increases intracellular free calcium. Proc. Natl. Acad. Sci. USA. 1992; 89: 2732–2736.

4. Ahlstrom M., Pekkinen M., Lamberg-Allardt C. Dexamethasone downregulates the expression of parathyroid hormone-related protein (PTHrP) in mesenchymal stem cells. Steroids. 2009; 74 (2): 277-282.

5. Alonso V., de Gortazar A.R., Ardura J.A. et al. Parathyroid hormone-related protein (107–139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. J. Cell. Physiol. 2008, 217, 717-727.

6. Amano K., Densmore M., Fan Y., Lanske B. Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones. Bone 2016; 83: 256-266.

7. Amizuka N., Henderson J.E., Hoshi K., Warshawsky H., Ozawa H., Goltzman D., Karaplis A.C. Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide gene deletion. Endocrinology. 1996; 137 (11): 5055-67.

8. Amizuka N., Henderson J.E., White J.H., Karaplis A.C., Goltzman D., Sasaki T., Ozawa H. Recent studies on the biological action of parathyroid hormone (PTH)-related peptide (PTHrP) and PTH/PTHrP receptor in cartilage and bone. Histol Histopathol. 2000; 15 (3): 957-70. doi: 10.14670/HH-15.957.

9. Amizuka N., Warshawsky H., Henderson J.E. et al. Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondralbone formation. J Cell Biol. 1994; 126 (6): 1611–1623.

10. Amling M., Neff L., Tanaka S. et al. Bcl-2 lies downstream of parathyroid hormonerelated peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. Journal of Cell Biology. 1997; 136: 205–213.

11. Ansari N., Ho P.W.M., Crimeen-Irwin B., Poulton I.J., Athena R. Brunt, Mark R. Forwood, Paola Divieti Pajevic, Jonathan H. Gooi, T. John Martin, Natalie A Sims. Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein. Journal of Bone and Mineral Research. 2018; 33 (1): 137– 153. doi: 10.1002/jbmr.3291

12. Ardawi M.S., Nasrat H.A., BA′Aqueel H.S. Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study. European Journal of Endocrinology. 1997; 137: 402–409.

13. Aya K., Tanaka H., Ichinose Y. et al. Expression of parathyroid hormonerelated peptide messenger ribonucleic acid in developing kidney. Kidney Int. 1999; 55 (5): 1696–1703.

14. Barlet J.P., Champredon C., Coxam V., Davicco M.J., Tressol J.C. Parathyroid hormone-related peptide might stimulate calcium secretion into the milk of goats. J Endocrinol. 1992 Mar; 132 (3): 353-9.

15. Beck F., Tucci J., Senior P.V. Expression of parathyroid hormone-related protein mRNA by uterine tissues and extraembryonic membranes during gestation in rats. J Reprod Fertil. 1993; 99: 343–352.

16. Bisello A., Horwitz M.J., Stewart A.F. Parathyroid hormone-related protein: an essential physiological regulator of adult bone mass. Endocrinology. 2004 Aug; 145 (8): 3551–3553.

17. Blomme E.A., Sugimoto Y., Lin Y.C., Capen C.C., Rosol T.J. Parathyroid hormonerelated protein is a positive regulator of keratinocyte growth factor expression by normal dermal fibroblasts. Mol Cell Endocrinol. 1999; 152 (1–2): 189-97.

18. Blomme E.A.G., Werkmeister J.R., Zhou H., Kartsogiannis V., Capen C.C., Rosol T.J. Parathyroid hormone related protein expression and secretion in a skin organotypic culture system. Endocrine. 1998; 8: 143–151.

19. Boileau G., Tenenhouse H.S., Desgroseillers L. et al. Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide 107–139 as a substrate and osteocalcin, PPi and phosphate as inhibitors. Biochem J. 2001; 355 (3): 707-713.

20. Bond H., Dilworth M.R., Baker B., Cowley E., Requena Jimenez A., Boyd R.D.H. et al. Increased maternofetal calcium flux in parathyroid hormone-related proteinnull mice. J. Physiol. 2008; 586: 2015–25.

21. Boras-Granic K., Dann P., VanHouten J. et al. Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production. PLoS ONE. 2014; 9 (5): e90418.

22. Boras-Granic K., Van Houten J., Hiremath M. et al. Parathyroid hormone-related protein is not required for normal ductal oralveolar development in the post-natal mammary gland. PLoS One. 2011; 6: e27278.

23. Botella A., Rekik M., Delvaux M., Davicco M.J., Barlet J.P., Frexinos J., Bueno L. Parathyroid hormone (PTH) and PTH-related peptide induce relaxation of smooth muscle cells from guinea pig ileum: interaction with vasoactive intestinal peptide receptors. Endocrinology. 1994; 135 (5): 2160-7.

24. Bowden S.J., Emly J.F., Hughes S.V., Powell G., Ahmed A., Whittle M.J., Ratcliffe J.G., Ratcliffe W.A. Parathyroid hormone-related protein in human term placenta and membranes. J Endocrinol. 1994 Aug; 142 (2): 217-24.

25. Braude S., Graham A., Mitchell D. Lymphoedema/hypercalcaemia syndrome mediated by parathyroid-hormone-related protein. Lancet 1991; 337: 140-141.

26. Bruns M.E., Ferguson J.E., Bruns D.E., Burton D.W., Brandt D.W., Juppner H., Segre G.V., Deftos L.J. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: Implications for secretion and function. American Journal of Obstetrics and Gynecology. 1995; 173 (3), Part 1: 739-746.

27. Bukoski R.D.1, Ishibashi K., Bian K. Vascular actions of the calcium-regulating hormones. Semin Nephrol. 1995; 15 (6): 536-49.

28. Burtis W.J., Fodero J.P., Gaich G., Debeyssey M., Stewart A.F. Preliminary characterization of circulating amino-and carboxyl-terminal fragments of parathyroid hormone related peptide in humoral hypocalcaemia of malignancy. J Clin Endocrinol Metab. 1992; 75 (4): 1110-1114.

29. Campos R.V., Asa S.L., Drucker D.J.: Immunocytochemical localization of parathyroid hormone-like peptide in the rat fetus. Cancer Res 1991; 51: 6351–6357.

30. Canario A.V.M., Rotllant J., Fuentes J., GuerreiroPM, RitaTeodosioH, PowerDM, ClarkMS. Novel bioactive parathyroid hormone and related peptides in teleost fish. FEBSLett 580: 291–299, 2006.

31. Cao G., Gu Z., Ren Y. et al. Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium. Endocrinology. 2009. 150: 561-569.

32. Care A.D., Abbas S.K., Pickard D.W., Barri M., Drinkhill M., Findlay J.B., White I.R., Caple I.W. Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. Exp. Physiol. 1990; 75: 605–608. doi: 10.1113/expphysiol.1990.sp003437.

33. Casado-Diaz А., Santiago Mora R., Quesada J.M. The N- and C-terminal domains of parathyroid hormone-related protein affect differently the osteogenic and adipogenic potential of human mesenchymal stem cells, Exp. Mol. Med. 2010; 42 (2): 87-98.

34. Cataisson C., Lieberherr M., Cros M., Gauville C., Graulet A.M., Cotton J., Calvo F., de Vernejoul M.C., Foley J., Bouizar Z. Autocrine effect of parathyroid hormone-related peptide and alternative signaling pathways during malignant progression in human SV40-immortalized breast cell lines. J Bone Miner Res. 2000; 15: 2129–2139.

35. Cebrian A., Garcia-Ocana A., Takane K.K. et al. Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro. Diabetes. 2002; 51 (10): 3003–3013.

36. Chen H.L., Demiralp B., Schneider A., Koh A.J., Silve C., Wang C.Y., McCauley L.K. Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells. J. Biol. Chem. 2002; 277: 19374–19381. doi: 10.1074/jbc.M108913200.

37. Cho Y.-M., Lewis D.A., Koltz P.F., Virgile Richard, Todd A Gocken, Thomas J Rosol, Raymond L Konger, Dan F SpandauJohn Foley Regulation of parathyroid hormonerelated protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes. Journal of Endocrinology. 2004; 181: 179–190.

38. Cho Y.M., Woodard G.L., Dunbar M., Gocken T., Jimenez J.A., Foley J.: Hair-cycle-dependent expression of parathyroid hormone-related protein and its type I receptor: evidence for regulation at the anagen to catagen transition. J Invest Dermatol 2003; 120: 715–727.

39. Chung U., Lanske B., Lee K., Li E., Kronenberg H. The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci USA 1998; 95: 13030-13035.

40. Clemens T.L., Cormier S., Eichinger A. et al. Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. Br J Pharmacol. 2001; 134: 1113–1136.

41. Colnot C. Cellular and molecular interactions regulating skeletogenesis. J Cell Biochem. 2005; 95 (4): 688-97.

42. Cornish J., Callon K.E., Nicholson G.C., Reid I.R. Parathyroid hormone-related protein-(107–139) inhibits bone resorption in vivo. Endocrinology. 1997; 138: 1299–1304. doi: 10.1210/endo.138.3.4990.

43. Cramer S.D., Chen Z., Peehl D.M. Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: Inactivation of PTHrP-stimulated camp accumulation in mouse osteoblasts. J. Urol. 1996; 156: 526–531. doi: 10.1016/S0022-5347 (01) 65919-6.

44. Crocker I., Kaur M., Hosking, D.J., Baker, P.N. Rescue of trophoblast apoptosis by parathyroid hormone-related protein. BJOG. 2002; 109: 218–20.

45. Curtis N.E., Ho P.W., King R.G., Farrugia W., Moses E.K., Gillespie M.T., Moseley J.M., Rice G.E., Wlodek M.E. The expression of parathyroid hormone-related protein mRNA and immunoreactive protein in human amnion and choriodecidua is increased at term compared with preterm gestation. J Endocrinol. 1997; 154 (1): 103-112.

46. Curtis N.E., King R.G., Moseley J.M., Ho P.W., Rice G.E., Wlodek M.E. Intrauterine expression of parathyroid hormone-related protein in normal and preeclamptic pregnancies. Placenta. 1998; 19: 595–601.

47. Curtis N.E., King R.G., Moseley J.M., Ho P.W, Rice G.E., Wlodek M.E. Preterm fetal growth restriction is associated with increased parathyroid hormone–related protein expression in the fetal membranes. Am J Obstet Gynecol. 2000; 183 (3): 700-5.

48. Curtis N.E., Thomas R.J., Gillespie M.T., King R.G., Rice G.E., Wlodek M.E. Parathyroid hormone-related protein (PTHrP) mRNA splicing and parathyroid hormone/PTHrP receptor mRNA expression in human placenta and fetal membranes. J Mol Endocrinol. 1998; 21 (2): 225-34.

49. Davenport T.G., Jerome-Majewska L.A., Papaioannou, V.E. Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development 2003; 130: 2263-2273.

50. De Castro L.F., Lozano D., Portal-Nunez S. et al. Comparison of the skeletal effects induced by daily administration of PTHrP (1–36) and PTHrP (107–139) to ovariectomized mice. JCellPhysiol. 2012; 227 (4): 1752–1760.

51. De Miguel F., Fiaschi-Taesch N., Lopez-Talavera J.C. et al. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology. 2001; 142 (9): 4096-4105.

52. Deftos L.J., Burton D.W., Brandt D.W., Pinar H., Rubin L.P. Neoplastic hormoneproducing cells of the placenta produce and secrete parathyroid hormone-related protein. Studies by immunohistology, immunoassay, and polymerase chain reaction. Lab Invest. 1994; 71 (6): 847-52.

53. Deng, A., Zhang, H., Hu, M., Liu, S., Gao, Q., Wang, Y., Guo, C. Knockdown of Indian hedgehog protein induces an inhibition of cell growth and differentiation in osteoblast MC3T3-E1 cells. Molecular Medicine Reports. 2017; 16 (6): 7987-7992. https:// doi.org/10.3892/mmr.2017.7669.

54. Di Nicolantonio R., Koutsis, K., Wlodek, M.E. Fetal versus maternal determinants of the reduced fetal and placental growth in spontaneously hypertensive rats. J. Hypertens. 2000; 18: 45–50.

55. Diamond G., Gonterman R.M., Anderson A.L., Keshav Menon, Carlos D. Offutt, Chad H. Weaver, William M. Philbrick, John Foley. Parathyroid Hormone Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin. Journal of Investigative Dermatology. 2006; 126: 2127–2134.

56. DiPette D.J., Christenson W., Nickols M.A., Nickols G.A. Cardiovascular responsiveness to parathyroid hormone (PTH) and PTH-related protein in genetic hypertension. Endocrinology. 1992 Apr; 130 (4): 2045-51.

57. Dua K., Leonhard S., Martens H., Abbas S.K., Care A.D. Effects of parathyroid hormone and parathyroid hormone-related protein on the rates of absorption of magnesium, calcium, sodium, potassium and phosphate ions from the reticulo-rumen of sheep. Exp Physiol. 1994 May; 79 (3): 401–8.

58. Dunba M.E., Young P., Zhang J.P. et al. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein. Dev Biol. 1998; 203: 75–89.

59. Dunne F.P., Ratcliffe W.A., Mansour P., Heath D.A. Parathyroid hormone related protein (PTHrP) gene expression in fetal and extra-embryonic tissues of early pregnancy Hum Reprod. 1994 Jan; 9 (1): 149-56.

60. Duval C., Dilworth M.R., Tunsterc S.J., Kimber S.J., Glazier J.D. PTHrP is essential for normal morphogenetic and functional development of the murine placenta. Developmental Biology. 2017; 430 (2): 325-336.

61. El-Hashash A.H., Esbrit P., Kimber S.J. PTHrP promotes murine secondary trophoblast giant cell differentiation through induction of endocycle, upregulation of giant-cellpromoting transcription factors and suppression of other trophoblast cell types. Differentiation. 2005; 73, Issue 4: 154-174. DOI: 10,1111 /
j.1432-0436.2005.00013.x

62. El-Hashash A.H.K., Kimber, S.J. PTHrP induces changes in cell cytoskeleton and Ecadherin and regulates Eph/Ephrin kinases and RhoGTPases in murine secondary trophoblast cells. Dev. Biol. 2006; 290: 13–31.

63. Eller-Vainicher C., Ossola M.W., Beck-Peccoz P., Chiodini I. PTHrP-associated hypercalcemia of pregnancy resolved after delivery: a case report. Eur J Endocrinol 2012; 66 (4): 753-756.

64. Emly J.F., Gregory J., Bowden S.J., Ahmed A., Whittle M.J., Rushton D.I., Ratcliffe W.A. Immunohistochemical localization of parathyroid hormone-related protein (PTHrP) in human term placenta and membranes. Placenta. 1994; 15 (6): 653-660.

65. Errazahi A., Lieberherr M., Bouizar Z., Rizk-Rabin M. PTH-1R responses to PTHrP and regulation by vitamin D in keratinocytes and adjacent fibroblasts. J Steroid Biochem Mol Biol. 2004; 89-90 (1-5): 381-5.

66. Errecart M.T., Ross J.G., Robb W., Warren C.W., Kann L., Collins J.L., Pateman B.C., Small M.L., Sundberg E.C. Methodology. J. Sch. Health. 1995; 65: 295–301. doi: 10.1111/j.1746-1561.1995.tb03377.x.

67. Esbrit P., Alvarez-Arroyo M.V., De Miguel F., Martin O., Martinez M.E., Caramelo C. C-terminal parathyroid hormone-related protein increases vascular endothelial growth factor in human osteoblastic cells. J. Am. Soc. Nephrol. 2000; 11: 1085–1092.

68. Farrugia W., de Gooyer T., Rice G.E., Moseley J.M., Wlodek M.E. Parathyroid hormone (1–34) and parathyroid hormone-related protein (1– 34) stimulate calcium release from human syncytiotrophoblast basal membranes via a common receptor. J Endocrinol 2000; 166: 689–695.

69. Farrugia W., Ho P.W., Rice G.E., Moseley J.M., Permezel M., Wlodek M.E. Parathyroid hormone-related protein (1–34) in gestational fluids and release from human gestational tissues. J Endocrinol 2000;
165: 657–662.

70. Fenton A.J., Kemp B.E., Hammonds R.G., Jr., Mitchelhill K., Moseley J.M., Martin T.J., Nicholson G.C. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107–111] Endocrinology. 1991; 129: 3424–3426. doi: 10.1210/endo-129-6-3424.

71. Fenton A.J., Kemp B.E., Kent G.N. et al. A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts. Endocrinology. 1991; 129 (4): 1762–1768.

72. Fenton A.J., Martin T.J., Nicholson G.C. Long-term culture of disaggregated rat osteoclasts: Inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP[107–139] J. Cell Physiol. 1993; 155: 1–7. doi: 10.1002/jcp.1041550102.

73. Ferguson J.E., Gorman J.V., Bruns D.E. et al. Abundant expression of parathyroid hormone-related protein in human amnion and its association with labor. Proc Natl Acad Sci USA 1992; 89: 8384-8388.

74. Ferguson J.E., Seaner R.M., Bruns D.E., Iezzoni J.C., and Bruns M.E. Expression and specific immunolocalization of the human parathyroid hormone/parathyroid hormone-related protein receptor in the uteroplacental unit. Am. J. Obstet. Gynecol. 1998; 179: 321–9.

75. Ferrari S.L., Rizzoli R. Bonjour J.P. Effects of epidermal growth factor on parathyroid hormone-related protein production by mammary epithelial cells. Journal of Bone and Mineral Research. 1994; 9 639–644.

76. Fhilbrick W.M., Wysolmersli J.J., Galbraith S. et al. Defining the roles of the parathyrPoid hormone-related protein in normal physiology. Physiological Reviews. 1996, 76, 127–173.

77. Fiaschi-Taesch N.M., Stewart A.F. Minireview: parathyroid hormone-related protein as an intracrine factor-trafficking mechanisms and functional consequences. Endocrinology. 2003, 144 (2): 407–411.

78. Foley J., Longely B.J., Wysolmerski J.J. et al. PTHrP regulates epidermal differentiation in adult mice. J Invest Dermatol 1998; 111: 1122–1128.

79. Freire-Maia N., Pinheiro M.: Ectodermal Dysplaias: A Clinical and Genetic Study. New York: Alan R. Liss, 1984.

80. Frieling J.S., Shay G., Izumi V., Aherne S.T., Saul R.G., Budzevich M., Koomen J., Lynch C.C. Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1–17. Oncogene. 2017; 36: 4498–4507; doi: 10.1038/onc.2017.70.

81. Gardella T.J., Juppner H. Molecular properties of the PTH/PTHrP receptor. Trends Endocrinol Metab. 2001; 12: 210–217. doi: 10.1016/S1043-2760 (01) 00409-X.

82. Gensure R.C. Parathyroid Hormone-Related Peptide and the Hair Cycle – is it the Agonists or the Antagonists that Cause Hair Growth? Exp Dermatol. 2014; 23 (12): 865-7.

83. Glatz J.A., Heath J.K., Southby J., O′Keeffe L.M., Kiriyama T., Moseley J.M., Martin T.J., Gillespie M.T. Dexamethasone regulation of parathyroid hormone-related protein (PTHrP) expression in a squamous cancer cell line. Mol Cell Endocrinol 101: 295–306, 1994.

84. Gonzalez-Suarez E., Jacob A.P., Jones J. et al. RANK ligand mediates progestininduced mammary epithelial proliferation and carcino-genesis. Nature. 2010; 468: 103–107.

85. Gordon J., Strewler M.D. The physiology of parathyroid hormone-related protein. NEngl J Med 2000; 342: 177–185.

86. Grill V., Hillary J., Ho P.M.W. et al. Parathyroid hormone-related protein: a possible endocrine function in lactation. Clin Endocrinol (Oxf) 1992; 37: 405-410.

87. Grill V., Ho P., Body J.J., Johanson N., Lee S.C. et al. Parathyroid hormonerelated protein: elevated levels in both humoral hypocalcaemia of malignancy and hypocalcaemia complicating metastatic breast cancer. J Clin Endocrinol Metab. 1991; 73 (6): 1309–1315

88. Gu Z., Liu Y., Zhang Y., Jin S., Chen Q., Goltzman D., Karaplis A., Miao D. Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function. PLoS One. 2012; 7:e41542. doi: 10.1371/journal.pone.0041542.

89. Gujral A., Burton D.W., Terkeltaub R.A. et al. PTHrP induces Interleukin 8 production by prostate cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence. Cancer Res. 2001. 61: 2282–2288.

90. Guo L., Qi S.-T., Miao D.-Q., Liang X.-W., Li H., Ou X.-H. et al. The roles of parathyroid hormone-like hormone during mouse preimplantation embryonic development. PLoS One. 2012; 7: e40528.

91. Halkali A., Wimalawansa S.J., Berentsen V., Avila E., Thota C.S., Larrea F. Calcitonin gene- and parathyroid hormone-related peptides in preeclampsia: effects of magnesium sulfate. Obstet Gynecol 2001; 97: 893–397.

92. Hastings R.H., Asirvatham A., Quintana R., Sandoval R., Dutta R., Burton D.W., Deftos L.J. Parathyroid hormone-related protein-(38–64) regulates lung cell proliferation after silica injury. Am. J. Physiol. Lung Cell Mol. Physiol. 2002; 283:L12–L21. doi: 10.1152/ajplung.00308.2001.

93. Hastings R.H., Quintana R.A., Sandoval R. et al. Proapoptotic effects of parathyroid hormone-related protein in type II pneumocytes. Am J Respir Cell MolBiol 2003; 29 (6): 733–742.

94. Hatsell, S.J., Cowin, P. Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development. 2006; 133: 3661–3670.

95. Hayman J.A., Danks J.K., Ebelig P.R., Mosley J.M., Kemp B.E., Martin T.J. Expression of parathyroid hormone related protein in normal skin and in tumors of skin and skin appendages. J Pathol. 1989; 158: 293–296.

96. Heath J.K., Southby J., Fukumoto S., O′Keeffe L.M., Martin T.J. &Gillespie M.T. Epidermal growth fa ctor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability. Biochemistry Journal 1995; 307 159–167.

97. Heffner L.J., Kumari, M., and Benoit, L.A. Secretion of the Vasoactive Peptides, Endothelin and Parathyroid Hormone-Related Peptide, by Decidual Explants From Pregnancies Complicated by Intrauterine Growth Restriction. J. Soc. Gynecol. Investig. 1999; 6: 273–277.

98. Hellman., Ridefelt P., Juhlin C., Akerstrom G., Rastad J. et al. Parathyroidlike regulation of parathyroid hormone-related protein release and cytoplasmic calcium in cytothrophoblast cells of human placenta. Arch Biochem Biophys. 1992; 293 (1): 174-180.

99. Henderson J.E., Amizuka N., Warshawsky H. et al. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Molecular and Cellular Biology.1995. 15. 4064–4075.

100. Henderson J.E., Kremer K., Rhim J.S., Goltzman D. Identification of adenylate cyclase receptors for parathyroid hormone like peptides on immortalized human keratinocytes. Endocrinology. 1992; 130: 449–457.

101. Hens J.R., Wysolmerski J.J. Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland. Breast Cancer Research. 2005; 7 (5): 220–224.

102. Hirai T., Chagin A.S., Kobayashi T. et al. Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life. Proc Nat Acad Sci U S A. 2011, 108 (1): 191–196.

103. Hiremath M., Wysolmerski J. Parathyroid hormone-related protein specifies the mammary mesenchyme and regulates embryonic mammary development. Journal of mammary gland biology and neoplasia. 2013. 18: 171–177.

104. Hirota Y., Anai T. Miyakawa I. Parathyroid hormone-related protein levels in maternal and cord blood. American Journal of Obstetrics and Gynecology. 1997; 177: 702–706.

105. Holick M.F., Chen M.L., Kong X.F., Sanan D.K.: Clinical uses for calciotropic hormones 1,25-dihydroxyvitamin D 3 and parathyroid hormone-related peptide in dermatology: a new perspective. J Investig Dermatol Symp Proc 1996; 1: 1–9.

106. Holick M.F., Chimeh F.N., Ray S.: Topical PTH (1–34) is a novel, safe and effective treatment for psoriasis: a randomized self-controlled trial and an open trial. Br J Dermatol 2003; 149: 370–376.

107. Holick M.F., Ray S., Chen T.C., Tian X., Persons K.S. A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice. Proc Natl Acad Sci USA 1994; 91: 8014-8016.

108. Hook V.Y., Burton D., Yasothornsrikul S. et al. Proteolysis of ProPTHrP (1–141) by «prohormonethiol protease» at multibasic residues generates PTHrP-related peptides: implications for PTHrP peptide production in lung cancer cells. BiochemBiophys Res Commun. 2001; 285 (4): 932-938.

109. Horwitz M.J., Tedesco M.B., Garcia-Ocana A. et al. Parathyroid hormone-related protein for the treatment of postmenopausal osteoporosis: defining the maximal tolerable dose. J Clin Endocrinol Metab. 2010 Mar; 95 (3): 1279–1287.

110. Iwamoto M., Kitagaki J., Tamamura Y., Gentili C., Koyama E., Enomoto H., Komori T., Pacifici M. and Enomoto-Iwamoto M. Runx2 expression and action in chondrocytes are regulated by retinoid signaling and parathyroid hormone-related peptide (PTHrP). Osteoarthritis Cartilage. 2003; 11: 6–15.

111. Jans D.A., Thomas R.J., Gillespie M.T. Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles. Vitam. Horm. Vitamins & Hormones. 2003. 66: 345–384.

112. Jemtland R., Divieti P., Lee K. and Segre G.V.: Hedgehog promotes primary osteoblast differentiation and increases PTHrP mRNA expression and iPTHrP secretion. Bone. 2003; 32: 611–620.

113. Jia K.Z., Jin S.L., ChunYao C. et al., Absence of PTHrP nuclear localization and C-terminus sequences leads to abnormal development of T cells. Biochimie. 2017; 138: 13-19.

114. Jobert A.S., Zhang P., Couvineau A. et al. Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J Clin Invest 1998; 102: 34-40.

115. Kaiser S.M., Laneuville P., Bernier S.M., Rhim J.S., Kremer R., Goltzman D. Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide. J Biol Chem 1992a; 267 (19): 13623–13628.

116. Kaiser S.M., Sebag M., Rhim J.S., Kremer R., Goltzman D.C. Antisensemediated inhibition of parathyroid hormone related peptide production in a keratinocyte cell line impedes differentiation. Mol Endocrinol. 1992b; 8: 139–147.

117. Kaji H., Sugimoto T., Kanatani M., Fukase M., Chihara K. Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation. Endocrinology. 1995; 136: 842–848. doi: 10.1210/endo.136.3.7867592.

118. Kamalakar A., Washam C.L., Akel N.S., Allen B.J., Williams D.K., Swain F.L., Leitzel K., Lipton A., Gaddy D., Suva L.J. PTHrP(12–48) modulates the bone marrow microenvironment and suppresses human osteoclast differentiation and lifespan. J. Bone Miner. Res. 2017; 32: 1421–1431. doi: 10.1002/jbmr.3142.

119. Karaplis A.C., Luz A., Glowacki J., Bronson R.T., Tybulewicz V.L., Kronenberg H.M., Mulligan R.C. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994; 8 (3): 277–289.

120. Karaplis A.C., He B., Nguyen M.T. et al. Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia. Endocrinology 1998; 139: 5255-5258.

121. Karperien M., Lanser P., Laat S.W. De, Boonstra J., Defize L.H.K. Parathyroid hormone related peptide mRNA expression during murine postimplantation development: evidence for involvement in multiple differentiation processes. Int. J. Dev. Biol. 1996; 40: 599–638.

122. Karperien M., van Dijk T.B., Hoeijmakers T., Cremers F., Abou-Samra A.B., Boonstra J., de Laat S.W., Defize L.H. Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes. Mech Dev. 1994; 47: 29–42.

123. Kawashima-Ohya Y., Satakeda H., Kuruta Y., Kawamoto T., Yan W., Akagawa Y., Hayakawa T., Noshiro M., Okada Y., Nakamura S. et al. Effects of parathyroid hormone (PTH) and PTH-related peptide on expressions of matrix metalloproteinase-2, -3, and -9 in growth plate chondrocyte cultures. Endocrinology. 1998; 139: 2120–2127. doi: 10.1210/endo.139.4.5941.

124. Kocabagli N., Riond J.L., Spichiger U.E. et al. Parathyroid hormone-related protein and calcium homeostasis during the periparturient period of dairy cows. Am. J. Vet. Res.1995. 56: 380-385.

125. Komori T. Signaling networks in RUNX2-dependent bone development. J Cell Biochem. 2011; 112: 750–755.

126. Kovacs C.S. Calcium and bone metabolism in pregnancy and lactation. J Clin Endocrinol. 2001; Metab 86 (6): 2344-2348.

127. Kovacs C.S., Chafe L.L., Woodland M.L., McDonald K.R., Fudge N.J., and Wookey P.J. Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange. Am. J. Physiol. Endocrinol. Metab. 2002; 282: E721–32.

128. Kovacs C.S., Ho C., Seidman C.E. Parathyroid calcium sensing receptor regulates fetal blood calcium and fetal-maternal calcium gradient independently of the maternal calcium levels. J Bone Min Res.1996; 22: S121.

129. Kovacs C.S., Kronenberg H.M. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev 1997; 18: 832–872.

130. Kovacs C.S., Lanske B., Hunzelman J.L., Guo J., Karaplis A.C., Kronenberg H.M. Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc. Natl. Acad. Sci. USA. 1996; 93: 15233–15238. doi: 10.1073/pnas.93.26.15233.

131. Kremer R., Karaplis A.C., Henderson J., Gulliver W., Banville D., Hendy G.N., Goltzman D. Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. Effect of growth factors and 1: 25 dihydroxyvitamin D3 on gene expression and secretion. J Clin Invest. 1991; 87: 884–893.

132. Kronenberg H.M. Developmental regulation of the growth plate. Nature. 2003; 423 (6937): 332-336.

133. Kronenberg H.M. PTHrP and skeletal development. Ann. N.Y. Acad. Sci. 2006; 1068: 1–13.

134. Kronenberg H.M., Chung U. The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate. Novartis Found Symp. 2001; 232: 144–157.

135. Lam M.H., Briggs L.J., Hu W., Martin T.J., Gillespie M.T., Jans D.A. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J. Biol. Chem. 1999; 274: 7391–7398. doi: 10.1074/jbc.274.11.7391.

136. Lam M.H., Olsen S.L., Rankin W.A., Ho P.W., Martin T.J., Gillespie M.T., Moseley J.M. PTHrP and cell division: expression and localization of PTHrP in a keratinocyte cell line (HaCaT) during the cell cycle. J Cell Physiol. 1997, 173 (3): 433-46.

137. Lanske B., Amling M., Neff L. et al. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J ClinInvest. 1999; 104: 399–407.

138. Lanske B., Karaplis A.C., Lee K. et al. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 1996; 273: 663-666.

139. Lanske B., Pajevic P.D., Kovacs C.S. et al. The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrin. 1998; 139 (12): p. 5194-5204.

140. Lee K., Deeds J.D., Segre G.V. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology. 1995; 136 (2): 453–463.

141. Long F., Zhang X.M., Karp S. et al. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development, 2001; 128: 5099–5108.

142. Luparello C. Midregion PTHrP and human breast cancer cells. Sci. World J. 2010; 10: 1016–1028.

143. Luparello C., Romanotto R., Tipa A., Sirchia R., Olmo N., Lopez de Silanes I., Turnay J., Lizarbe M.A., Stewart A.F. Midregion parathyroid hormone-related protein inhibits growth and invasion in vitro and tumorigenesis in vivo of human breast cancer cells. J. Bone Miner. Res. 2001; 16: 2173–2181. doi: 10.1359/jbmr.2001.16.12.2173.

144. Luparello C., Sirchia R., Lo Sasso B. Midregion PTHrP regulates rip1 and caspase expression in mda-mb231 breast cancer cells. Breast Cancer Res. Treat. 2008; 111: 461–474. doi: 10.1007/s10549-007-9816-0.

145. Luparello C., Sirchia R., Pupello D. PTHrP [67–86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and mmp-1 expression 5. J. Cell Sci. 2003; 116: 2421–2430. doi: 10.1242/jcs.00472.

146. Macgill K., Moseley J.M., Martin T.J., Brennecke SP, Rice GE, Wlodek M.E. Vascular effects of PTHrP (1–34) and PTH (1–34) in the human fetal-placental circulation. Placenta. 1997; 18 (7): 587–92.

147. Macica C., Liang G., Nasiri A. et al. Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis Rheum. 2011; 63: 3333–3343.

148. Macica C.M., Broadus A.E. PTHrP regulates cerebral blood flow and is neuroprotective. Am J Physiol Regul Integr Comp Physiol 2003; 284 (4): 1019–1020.

149. Maioli E., Fortino V., Pacini A. Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternaland Fetal Failures. Biology of Reproducnion. 2004; 71: 1779–1784.

150. Mandsager N., Brewer A., and Myatt L. Vasodilator effects of parathyroid hormone, parathyroid hormone-related protein, and calcitonin gene-related peptide in the human fetal-placental circulation. J. Soc. Gynecol. Investig. 1994; 67: 1263–1269.

151. Mangin M., Ikeda K., Dreyer B.E., Milstone L., Broadus A.E. Two distinct tumor-derived, parathyroid hormone-like peptides result from alternative ribonucleic acid splicing. Mol Endocrinol. 1988; 2 (11): 1049–55.

152. Martin T.J. Osteoblast-derived PTHrP is a physiological regulator of bone formation. J. Clin. Invest. 2005; 115: 2322–2324. doi: 10.1172/JCI26239.

153. Martin T.J. Parathyroid hormone-related protein, its regulation of cartilage and bone development, and role in treating bone diseases. Physiol. Rev. 2016; 96: 831–871. doi: 10.1152/physrev.00031.2015.

154. Martin T.J., Moseley J.M., Williams E.D. Parathyroidhormone–relatedprotein: hormone and cytokine. J Endocrinol, 1997; 154: 23–37.

155. Massfelder T., Dann P., Wu T.L. et al. Opposing mitogenic and antimitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: A critical role for nuclear targeting. Proc. Natl. Acad. Sci. USA 1997, 94, 13630–13635.

156. Mazzocchi G., Aragona F., Malendowicz L.K. et al. PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells. Am. J. Physiol. Endocrinol. Metab., 2001, 280: 209-213.

157. McCauley L.K., Martin T.J. Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine. J Bone Miner Res. 2012, 27: 1231–1239.

158. Mecklenburg L., Tobin D.J., Muller-Rover S., Handjiski B., Wendt G., Peters E.M. et al. Active hair growth (anagen) is associated with angiogenesis. J Invest Dermatol. 2000; 114: 909–16.

159. Merendino J.J., Insogna K.L., Milstone L.M., Broadus A.E., Stewart AF, Broadus A.E., Stewart A.F. Parathyroid hormone related-like protein from cultured human keratinocytes. Science. 1986; 231: 388–390.

160. Meziani F., Tesse A., Welsch S., Kremer H., Mariette Barthelmebs, RamarosonAndriantsitohaina, Francis Schneider, Alexis Gairard; Expression and Biological Activity of Parathyroid Hormone-Related Peptide in Pregnant Rat Uterine Artery: Any Role for 8-IsoProstaglandin F2α?, Endocrinology. 2008; 149 (2): 626–633.

161. Meziani F., Van Overloop B., Schneider F., Gairard A. Parathyroid hormonerelated protein-induced relaxation of rat uterine arteries: influence of the endothelium during gestation. J Soc Gynecol Investig. 2005; 12: 14 –19.

162. Miao D., He B., Jiang Y., Kobayashi T., Soroceanu M.A., Zhao J., Su H., Tong X., Amizuka N., Gupta A. et al. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1–34. J. Clin. Invest. 2005; 115: 2402–2411. doi: 10.1172/JCI24918.

163. Miao D., He B., Karaplis A.C. Parathyroid hormone is essential for normal fetal bone formation. J. Clin. Invest. 2002. 109: 1173–1182.

164. Miao D., Su H., He B., Gao J., Xia Q., Zhu M., Gu Z., Goltzman D., Karaplis A.C. Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. Proc Natl Acad Sci USA. 2008; 105 (51): 20309–20314.

165. Millar S.E. Molecular mechanisms regulating hair follicle development. J Invest Dermatol. 2002; 118: 216–25.

166. Milstone L.M.: Effector functions of epidermal keratinocytes. Ann NY Acad Sci 1988; 548: 1–3.

167. Moniz C., Burton, P.B., Malik, A.N., Dixit, M., Banga, J.P., Nicolaides, K. et al. Parathyroid hormone-related peptide in normal human fetal development. J. Mol. Endocrinol.1990; 5: 259–266.

168. Moseley J.M., Hayman, J.A., Danks, J.A., Alcorn, D., Grill, V., Southby, J. et al. Immunohistochemical Detection of Parthyroid Hormone-Related Protein in Human Fetal Epithelia. J. Clin. Endocinology Metab. 1991; 73: 478–484.

169. Murray P., Edgar, D. Regulation of the differentiation and behaviour of extra-embryonic endodermal cells by basement membranes. J. Cell Sci.2001; 114: 931–9.

170. Naafs M.A.B. Parathyroid Hormone Related Peptide (PTHrP): A Mini-Review. Endocrinol Metab Int J. 2017; 5 (6): 00139.

171. Nguyen M., He B., Karaplis A. Nuclear forms of parathyroid hormone-related peptide are translated from non-aug start sites downstream from the initiator methionine. Endocrinology. 2001; 142: 694–703. doi: 10.1210/endo.142.2.7944.

172. Nowak R., Haimovici, F., Biggers, J.D., and Erbach, G.T. Transforming growth factor-beta stimulates mouse blastocyst outgrowth through a mechanism involving parathyroid hormone-related protein. Biol. Reprod. 1999; 60: 85–93.

173. Nussdorfer G.G., Bahcelioglu M., Neri G., Malendowicz L.K. Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus-pituitary-adrenal axis. Peptides 21: 309–324, 2000.

174. Orloff J.J., Ganz M.B., Ribaudo A.E., Burtis W.J., Reiss M., Milstone L.M., Stewart A.F. Analysis of PTHrP binding and signal transduction mechanisms in benign and malignant squamous cells. Am J Physiol 1992; 262: E599–E607.

175. Orloff J.J., Kats Y., Urena P., Shipani E., Vasavada R.C., Philbrick W.M., Behal A., Abou-Samra A.B., Segre G.V., Juppner H. Further evidence for a novel receptor for amino-terminal parathyroid hormone related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology. 1995; 136: 3016–3023.

176. Orloff J.J., Reddy D., de Papp A.E., Yang K.H., Soifer N.E., Stewart A.F. Parathyroid hormone-related protein as a prohormone: Posttranslational processing and receptor interactions. Endocr Rev. 1994; 15: 40–60.

177. Park S.I., McCauley L.K. Nuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cells. Endocr Relat Cancer. 2012; 19: 243-254.

178. Peters E.M., Foitzik K., Paus R., Ray S., Holick M.F. A new strategy for modulating chemotherapy-induced alopecia, using PTH/PTHrP receptor agonist and antagonist. J Invest Dermatol. 2001; 117: 173–8.

179. Philbrick W.M., Wysolmerski J.J., Galbraith S., Holt E, Orloff J.J., Yang K.H., Vasavada R.C., Weir E.C., Broadus A.E., Stewart A.F. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev. 1996; 76 (1): 127-73.

180. Phippard D.J., Weber-Hall S.J., Sharpe P.T. et al. Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development. 1996; 122: 2729-2737.

181. Piepkorn M., Pittelkow M.R., Cook P.W. Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors. Journal of Investigative Dermatology. 1998; 111 715–721.

182. Pioszak A.A., Parker N.R., Gardella T.J., Xu H.E. Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J. Biol. Chem. 2009; 284: 28382–28391. doi: 10.1074/jbc.M109.022905.

183. Pittelkow M.R., Cook P.W., Shipley G.D., Derynck R. & Coffey R.J. Jr Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. Cell Growth and Differentiation. 1993; 4 513–521.

184. Pun K.K., Arnaud C.D., Nissenson R.A.: Parathyroid hormone receptors in human dermal fibroblasts: structural and functional characterization. J Bone Miner Res 1988; 3: 453–460.

185. Rakopoulos M., Vargas S.J., Gillespie M.T., Ho P.W., Diefenbach-Jagger H., Leaver D.D., Grill V., Moseley J.M., Danks J.A., Martin T.J. Production of parathyroid hormone-related protein by the rat mammary gland in pregnancy and lactation. Am J Physiol Endocrinol Metab 263: E1077–E1085, 1992.

186. Ramirez M.M., Fraher L.J., Goltzman D., Hendy G.N., Matthews S.G., Sangha R., Challis J.R. Immunoreactive parathyroid hormone-related protein: its association with preterm labor. European Journal of Obstetrics, Gynecology, and Reproductive Biology [01 Nov 1995, 63 (1): 21–26. DOI: 10.1016/0301–2115 (95) 98586-S).

187. Reti N.G., Lappas M., Huppertz B. et al. Effect of high oxygen on placental function in short-term explant cultures. Cell Tissue Res. 2007; 328: 607–616 doi: 10.1007/s00441-006-0375-1.

188. Robinson G.W., Karpf A.B., Kratochwil K. Regulation of mammary gland development by tissue interaction. J. Mammary Gland Biol. Neoplasia. 1999; 4: 9–19.

189. Rodda C.P., Kubota M., Heath J.A. et al. Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcemia of malignancy. JEndocrinol. 1998; 117: 261–271.

190. Rosol, T.J., Grone, A., Werkmeister, J.R. et al. Production of parathyroid hormonerelated protein by normal and neoplastic keratinocytes Journal of Bone and Mineral Metabolism J Bone Miner Metab. 1994; 12 (1): 161–164.

191. Rotllant J., Guerreiro P.M., Anjos L., Redruello B., Canario A.V., Power D.M. Stimulation of cortisol release by the N terminus of teleost parathyroid hormone-related protein in interrenal cells in vitro. Endocrinology 146: 71–76, 2005.

192. Rouffet J., Barlet J.P. Parathyroid hormone-related peptide (PTHrP) and bone metabolism. Arch Physiol Biochem. 1995. 103: 3–13.

193. Rubin L.P., Kovacs, C.S., Paepe, M.E. De, Tsai, S.-W., Torday, J.S., and Kronenberg, H.M. Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev. Dyn. 2004; 230: 278–89.

194. Safer J.D., Ray S., Holick M.F.: A topical parathyroid hormone/parathyroid hormone-related peptide receptor antagonist stimulates hair growth in mice. Endocrinology 2007; 148: 1167–1170.

195. Sato K. Hypercalcemia during pregnancy and lactation and a case report of hypercalcemic crisis after delivery due to excessive production of PTH-related protein (PTHrP) without malignancy (humoral hypercalcemia of pregnancy). Endocr J. 2008; 55 (6): 959-966.

196. Satokata I., Ma L., Ohshima H. et al. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat. Genet. 2000; 24: 391–395.

197. Schilli M.B., Ray S., Paus R., Obi-Tabot E., Holick M.F.: Control of hair growth with parathyroid hormone (7–34). J Invest Dermatol 1997; 108: 928–932.

198. Schilling T., Pecherstorfer M., Blind E., Kohl B., Wagner H., Ziegler R., Raue F. Glucocorticoids decrease the production of parathyroid hormone-related protein in vitro but not in vivo in the Walker carcinosarcoma 256 rat model. Bone 18: 315–319, 1996.

199. Schipani E., Langman C.B., Parfitt A.M. et al. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen′s metaphyseal chondrodysplasia. N Engl J Med 1996; 335: 708-714.

200. Schipani E., Lanske B., Hunzelman J. et al. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Nat Acad Sci USA 1997; 94: 13689–13694.

201. Schipani E., Provot S. PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development. Birth Defects Res C Embryo Today. 2003; 69 (4): p. 352-362.

202. Schluter K.D. PTH and PTHrP: similar structures but different functions. Physiology.1999.Vol. 14. 6, 243-249.

203. Sehgal V.N., Srivastava G., Aggarwal A.K., Midha R.: Hair biology and its comprehensive sequence in female pattern baldness: diagnosis and treatment modalities. Part I. Skinmed. 2013; 11: 39–45.

204. Seitz P.K., Cooper K.M., Ives K.L. et al. Parathyroid hormone-related peptide production and action in a myoepithelial cell line derived from normal human breast. Endocrinology.1993. 133 (3): 1116–1124.

205. Seki K., Wada S., Nagata N., Nagata I. Parathyroid hormone-related protein during pregnancy and the perinatal period. Gynecologic and obstetric investigation; 1994; 37 (2) 83-6.

206. Senior P.V., Heath D.A., Beck F. Expression of parathyroid hormone-related protein mRNA in the rat before birth: demonstration by hybridization histochemistry. J Mol Endocrinol. 1991; 6: 281–290.

207. Sharpe G.R., Dillon J.P., Durham B., Gallagher J.A., Fraser W.D. Human keratinocytes express transcripts for three isoforms of parathyroid hormone-related protein (PTHrP), but not for the parathyroid hormone/PTHrP receptor: effects of 1,25 (OH)2 vitamin D3. Br J Dermatol. 1998; 138 (6): 944-51.

208. Sherafat-Kazemzadeh. R., Schroeder J.K., Kessler C.A., Handwerger S. Parathyroid Hormone-Like Hormone (PTHLH) Represses Decidualization of Human Uterine Fibroblast Cells by an Autocrine/Paracrine Mechanism. J Clin Endocrinol Metab. 2011; 96 (2): 509–514.

209. Simmonds C.S., Kovacs C.S. Role of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in regulating mineral homeostasis during fetal development. Crit Rev Eukaryot Gene Expr. 2010; 20: 235–273.

210. Skrok A., Bednarczuk Т., Skwarek A., Popow М., Rudnicka L., Olszewska М. (The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia. Skin Pharmacol Physiol. 2015; 28 (4): 213-25.

211. Song T., Wang Y., Li H., Chen L., Liu J., Chen X., Li X., Li X., Li L., Lian Q. and Ge R.-S. Parathyroid Hormone-Related Protein Promotes Rat Stem Leydig Cell Differentiation. Front. Physiol. 2017; 8: 911. doi: 10.3389/fphys.2017.00911.

212. Sowers M.F., Hollis B.W., Shapiro B. et al. Elevated parathyroid hormone-related peptide associated with lactation and bone density loss. JAMA 1996; 276: 549-554.

213. Stewart A.F., Cain R.L., Burr D.B. et al. Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1–34, parathyroid hormone-related protein 1–36, and SDZ-parathyroid hormone 893. J. Bone Miner. Res. 2000, 15: 1517–1525.

214. Strewler G.J. The physiology of parathyroid hormone-related protein. New Eng J Med. 2000; 342: 177–185.

215. Strid H., Care A., Jansson T., Powell T. Parathyroid hormone-related peptide (38-94) amide stimulates atp-dependent calcium transport in the basal plasma membrane of the human syncytiotrophoblast. J. Endocrinol. 2002; 175: 517–524. doi: 10.1677/joe.0.1750517.

216. Stuart W.D., Maeda S., Khera P. et al. Parathyroid hormone-related protein induces G1phase growth arrest of vascular smooth muscle cells. Am J PhysiolEndocrinolMetab. 2000; 279 (1): 60–67.

217. Suehiro M., Murakami M., Fukuchi M. Circulating forms of immunoreactive parathyroid hormone-related protein for identifying patients with humoral hypercalcemia of malignancy: A comparative study with C-terminal(109–141)- and N-terminal(1–86)-region-specific PTHrP radioassay. Ann. Nucl. Med. 1994; 8: 231–237. doi: 10.1007/BF03165025.

218. Swan K.L., Wysolmerski J.J. in Endocrinology: Adult and Pediatric (Seventh Edition). Charter 64-Hypercalcemia of Malignancy. 2016; Pages 1125-1134.

219. Thiede M.A., Daifotis A.G., Weir E.C., Brines M.L., Burtis W.J., Ikeda K., Dreyer B.E., Garfield R.E., Broadus A.E. Intrauterine occupancy controls expression of the parathyroid hormone-related peptide gene in preterm rat myometrium. Proc Natl Acad Sci U S A 1990; 87: 6969–6973

220. Thomson M., McCarroll J., Bond J., Gordon-Thomson C., Williams D.E., Moore G.P.: Parathyroid hormone-related peptide modulates signal pathways in skin and hair follicle cells. Exp Dermatol 2003; 12: 389–395.

221. Thota C.S., Reed, L.C., Yallampalli, C. Effects of parathyroid hormone like hormone (PTHLH) antagonist, PTHLH(7–34), on fetoplacental development and growth during midgestation in rats. Biol. Reprod. 2005; 73: 1191–8.

222. Tian F., Wu M., Deng L., Guochun Zhu, Junqing Ma, Bo Gao, Lin Wang, YiPing Li, Wei Chen. Core binding factor beta (Cbfβ) controls the balance of chondrocyte proliferation and differentiation by upregulating Indian hedgehog (Ihh) expression and inhibiting parathyroid hormone-related protein receptor (PPR) expression in postnatal cartilage and bone formation. Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research 2014, 29 (7): 1564-1574.

223. Toribio R.E., Brown H.A., Novince C.M., Marlow B., Hernon K., Lanigan L.G., Hildreth B.E.III, Werbeck J.L., Shu S.T., Lorch G., Carlton M., Foley J., Boyaka P., McCauley L.K., Rosol T.J. The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB J. 2010; 24 (6): 1947–1957.

224. Truant R., Cullen B.R. The arginine-rich domains present in human immunodeficiency virus type 1 tat and rev function as direct importin beta-dependent nuclear localization signals. Mol. Cell Biol. 1999; 19: 1210–1217. doi: 10.1128/MCB.19.2.1210.

225. Uemura H., Yasui T., Yoneda N. et al. Measurement of N- and C-terminal-region fragments of parathyroid hormone-related peptide in milk from lactating women and investigation of the relationship of their concentrations to calcium in milk // J. Endocrinol. – 1997. – Vol. 153, № 3. – P445-451.

226. Urena P., Kong X.F., Abou-Samra A.B., Juppner H., Kronenberg H.M., Potts J.T., Segre G.V. Parathyroid hormone PTH/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues. Endocrinology. 1993; 133: 617–623.

227. Valin A., Garcia-Ocana A., De Miguel F., Sarasa J.L., Esbrit P. Antiproliferative effect of the c-terminal fragments of parathyroid hormone-related protein, PTHrP-(107–111) and (107–139), on osteoblastic osteosarcoma cells. J. Cell Physiol. 1997; 170: 209–215. doi: 10.1002/(SICI) 1097-4652 (199702) 170:2<209::AID-JCP13>3.0.CO; 2-C.

228. Van de Stolpe A., Karperien M., Lowik C.W., Juppner H., Segre G.V., Abou-Samra A.B., de Laat S.W., Defize L.H. Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation. J Cell Biol. 1993; 120: 235–243.

229. Van Houten J.N., Dann P., Stewart A.F. et al. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. J Clin Invest, 2003; 112 (9): 1429–1436.

230. Van Houten J.N., Wysolmerski J.J. Low estrogen and high parathyroid hormonerelated peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology. 2003; 144 (12): 5521-5529.

231. Veltmaat J.M., Relaix F., Le L.T. et al. Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development. 2006; 133: 2325-2335.

232. Vortkamp A., Lee K., Lanske B., Segre G.V., Kronenberg H.M., Tabin C.J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. 1996 Aug 2; 273 (5275): 613-22.

233. Walsh C.A., Birch M.A., Fraser W.D., Lawton R., Dorgan J., Walsh S., Sansom D., Beresford J.N., Gallagher J.A. Expression and secretion of parathyroid hormone-related protein by human bone-derived cells in vitro: effects of glucocorticoids. J Bone Miner. Res. 10: 17–25, 1995.

234. Washam C.L., Byrum S.D., Leitzel K., Ali S.M., Tackett A.J., Gaddy D., Sundermann S.E., Lipton A., Suva L.J. Identification of PTHrP(12–48) as a plasma biomarker associated with breast cancer bone metastasis. Cancer Epidemiol. Biomarkers Prev. 2013; 22: 972–983. doi: 10.1158/1055-9965.EPI-12–1318-T.

235. Watson P.H., Fraher L.J., Hendy G.N., Chung U.I., Kisiel M., Natale B.V., Hodsman A.B. 2000 Nuclear localization of the type I PTH/PTHrP receptor in rat tissues. J Bone Miner Res. 2000; 15: 1033–1044.

236. Weilbaecher K.N., Guise T.A., McCauley L.K. Cancer to bone: a fatal attraction. Nat Rev Cancer. 2011; 11 (6): 411–25.

237. Weiss S., Hennig T., Bock R. et al. Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells. J. Cell Physiol. 2010. 223: 84-93.

238. Werkmeister J.R., Blomme E.A., Weckmann M.T., GroneA, McCauley L.K., Wade A.B., O′Rourke J., Capen C.C., Rosol T.J. Effect of transforming growth factor-beta1 on parathyroid hormone-related protein secretion and mRNA expression by normal human keratinocytes in vitro. Endocrine. 1998; 8 (3): 291-9.

239. Werkmeister J.R., Merryman J., McCauley L.K., Horton J.E., Capen C., Rosol T.J. Parathyroid Hormone-Related Protein Production by Normal Human Keratinocytes in vitro. Experimental Cell Research. 1993; 208 (1): 68-74.

240. Whitfield J.F. Parathyroid hormone-related protein (PTHrP): an ancient string of cytokines with many known and still unknown functions. In Novel Aspects of PTHrP Physiopathology; Luparello, C., Ed; Nova Science Publishers: New York, NY, USA, 2007; pp. 1–25.

241. Whitfield J.F., Balu R., Chakravarthy B.R., Durkin J.P., Issacs R.J., Jouishome H., Sikorska M., Williams R.E., Rixon R.H. Parathyroid hormone stimulates protein kinase C but not adenylcyclase in mouse epidermal keratinocytes. J Cell Physiol. 1992; 150: 299–303.

242. Whitfield J.F., Isaacs R.J., Chakravarthy B.R., Durkin J.P., Morley P., Neugebauer W., Williams R.E., Willick G., Rixon R.H. C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107–111) and (107–139), and the n-terminal PTHrP-(1-40) fragment stimulate membrane-associated protein kinase c activity in rat spleen lymphocytes. J. Cell Physiol. 1994; 158: 518–522. doi: 10.1002/jcp.1041580317.

243. Williams E.D., Major B.J., Martin T.J., Moseley J.M., Leaver D.D. Effect of antagonism of the parathyroid hormone (PTH)/PTH-related protein receptor on decidualization in rat uterus. J Reprod Fertil. 1998; 112: 59–67.

244. Wlodek M.E., Di Nicolantonio R., Westcott K.T., Farrugia W., Ho P.W., Moseley J.M. PTH/PTHrP receptor and mid-molecule PTHrP regulation of intrauterine PTHrP: PTH/PTHrP receptor antagonism increases SHR fetal weight. Placenta. 2004; 25 (1): 53-61.

245. Wlodek M.E., Ho P.W., Rice G.E., Moseley J.M., Martin T.J., Brennecke SP Parathyroid hormone-related protein (PTHrP) concentrations in human amniotic fluid during gestation and at the time of labour. Reproduction, Fertility and Development. 1995; 7 1509–1513

246. Wlodek M.E., Koutsis K., Westcott K.T., Ho P.W., Di Nicolantonio R., Moseley J.M. The spontaneously hypertensive rat fetus, not the mother, is responsible for the reduced amniotic fluid PTHrP concentrations and growth restriction. Placenta. 2001 Aug; 22 (7): 646-51.

247. Wlodek M.E., Westcott K.T., Ho P.W., Serruto A., Di Nicolantonio R., Farrugia W., Moseley J.M. Reduced fetal, placental, and amniotic fluid PTHrP in the growthrestricted spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol. 2000 Jul; 279 (1): R31–8.

248. Wlodek M.E., Westcott K.T., O′Dowd R., Serruto A., Wassef L., Moritz K.M., Moseley J.M. Uteroplacental restriction in the rat impairs fetal growth in association with alterations in placental growth factors including PTHrP. Am J Physiol Regul Integr Comp Physiol. 288: R1620–R1627, 2005; doi: 10.1152/ajpregu.00789.2004.

249. Wojcik S.F., Schanbacher F.L., McCauley L.K., Zhou H., Kartsogiannis V., Capen C.C., Rosol T.J. Cloning of bovine parathyroid hormone-related protein (PTHrP) cDNA and expression of PTHrP mRNA in the bovine mammary gland. J Mo lEndocrinol 20: 271–280, 1998.

250. Wu T.L., Soifer N.E., Burtis W.J., Milstone L.M., Stewart A.F. Glycosylation of parathyroid hormone-related peptide secreted by human epidermal keratinocytes. J Clin Endocrinol Metab. 1991 Nov; 73 (5): 1002-7.

251. Wu T.L., Vasavada R.C., Yang K., Massfelder T., Ganz M., Abbas S.K., Care A.D., Stewart A.F. Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein. J. Biol. Chem. 1996; 271: 24371–24381. doi: 10.1074/jbc.271.40.24371.

252. Wysolmerski J.J. Parathyroid hormone-related protein: An update. Clin. Endocrinol. Metab. 2012, 97, 2947–2956.

253. Wysolmerski J.J., Philbrick W.M., Dunbar M.E. et al. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 1998; 125 1285–1294.

254. Wysolmerski J.J., Philbrick W.M., Zhou J. et al. Overexpression of parathyroid hormone related protein in the skin of transgenic mice interferes with hair follicle development. Proc Natl Acad Sci USA. 1994; 91: 1133–1137.

255. Wysolmerski J.J., Stewart A.F. The physiology of parathyroid hormone-related protein: An emerging role as a developmental factor. Annu Rev Physiol. 1998. 40: 431-460.

256. Zhang K., Zhang F.J., Zhao W.J., Xing G.S., Bai X., Wang Y. Effects of parathyroid hormone-related protein on osteogenic and adipogenic differentiation of human mesenchymal stem cells. Eur. Rev. Med. Pharmacol. Sci. 2014; 18: 1610–1617.

257. Zhang P., Jobert A.S., Couvineau A., Silve C.A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. J Clin Endocrinol Metab 1998; 83: 3365-3368.

258. Zhao Q., Brauer P.R., Xiao L., Michael H. McGuire, John A. Yee. Expression of parathyroid hormone-related peptide (PTHrP) and its receptor (PTH1R) during the histogenesis of cartilage and bone in the chicken mandibular process. J. Anat. 2002; 201: 137–151.

259. Zheng H.L., Li H., Sun Y.S. et al. Parathyroid hormone-related peptide (PTHrP): prokaryotic expression, purification, and preparation of a polyclonal antibody. Genetics and Molecular Research, 2014, 13 (3): 6448–6454.

260. Zhou L.X., Nemere I., Norman A.W. A parathyroid-related peptide induces transcaltachia (the rapid, hormonal stimulation of intestinal Ca2+ transport). Biochem Biophys Res Commun 186: 69–73, 1992.

261. Zuscik M.J., O′Keefe R.J., Gunter T.E. et al: Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A. J Orthop Res. 2002, 20 (5): 1079–1090.